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促分裂原活化蛋白激酶3 (细胞外信号调节激酶1/2) 单克隆抗体

P44/42 MAPK (ERK1/2) Monoclonal Antibody

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商品信息

产品英文名称 P44/42 MAPK (ERK1/2) Monoclonal Antibody
免疫原 合成多肽
宿主 小鼠
反应性 人, 大鼠, 小鼠
应用 IHC-P, WB
实验建议 最佳的工作稀释比例需要客户摸索优化。建议的起始尝试的稀释比为:WB:1:1000-1:2000,IHC-P:1:50-1:100。
克隆性 单克隆
纯化工艺 使用表位特异性的免疫原,通过亲和层析,从小鼠腹水中亲和纯化抗体。

商品属性

产品形式 液体溶液
浓度 1 mg/ml
储存缓冲液 含有50%甘油,0.5%BSA和0.13%叠氮化钠的PBS缓冲液。
保存建议 自发货之日起,-20°C可稳定保存1年。为最大限度的避免损失,请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。
运输条件 蓝冰运输
警告 本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。

附加信息

背景 MAPK1 (mitogen-activated protein kinase 1) encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs, act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for MAPK1.
基因ID 5594/5595
别名 MAPK3; ERK1; PRKM3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p
其它 该抗体可检测内源蛋白
蛋白质ID P27361/P28482

图片及说明

Fig.1. Western blot analysis of 1) Mouse Brain Tissue, 2) Rat Brain Tissue with P44/42 MAPK (ERK1/2) Mouse mAb diluted at 1:2000.

Fig.1. Western blot analysis of 1) Mouse Brain Tissue, 2) Rat Brain Tissue with P44/42 MAPK (ERK1/2) Mouse mAb diluted at 1:2000.

Fig.2. Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma using P44/42 MAPK (ERK1/2) Mouse mAb diluted at 1:200.

Fig.2. Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma using P44/42 MAPK (ERK1/2) Mouse mAb diluted at 1:200.

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