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基质金属蛋白酶2小鼠单克隆抗体 (1H1)

MMP2 Mouse Monoclonal Antibody (1H1)

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商品信息

产品英文名称 MMP2 Mouse Monoclonal Antibody (1H1)
免疫原 合成多肽: MMP2多肽,INTERNAL
宿主 小鼠
反应性 人, 大鼠, 小鼠
应用 IHC-P
实验建议 最佳的工作稀释比例需要客户摸索优化。建议的起始尝试的稀释比为:IHC-p:1:100-200。
克隆性 单克隆
纯化工艺 使用表位特异性的免疫原,通过亲和层析,从小鼠腹水中亲和纯化抗体。

商品属性

产品形式 液体溶液
浓度 1 mg/ml
储存缓冲液 含有50%甘油,0.5%BSA和0.02%叠氮化钠的PBS缓冲液。
保存建议 自发货之日起,-20°C可稳定保存1年。为最大限度的避免损失,请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。
运输条件 蓝冰运输
警告 本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。

附加信息

背景 MMP2 (matrix metallopeptidase 2) is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in MMP2 have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
基因ID 4313
别名 MMP2
其它 该抗体可检测内源蛋白
蛋白质ID P08253

图片及说明

Fig.1. Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma Tissue using MMP2 Mouse mAb diluted at 1:200.

Fig.1. Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma Tissue using MMP2 Mouse mAb diluted at 1:200.

Fig.2. Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using MMP2 Mouse mAb diluted at 1:200.

Fig.2. Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using MMP2 Mouse mAb diluted at 1:200.

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