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内收蛋白γ多克隆抗体

Adducin γ Polyclonal Antibody

浏览次数(29) 文献引用(0) 货号(ABP50607)
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商品信息

产品英文名称 Adducin γ Polyclonal Antibody
免疫原 合成多肽:来源于中间区域的人源蛋白Adducin γ. 氨基酸序列为: 400-480
宿主
反应性 人, 大鼠, 小鼠
应用 ELISA, IF, IHC-P, WB
实验建议 最佳的工作稀释比例需要客户摸索优化。建议的起始尝试的稀释比为:WB:1:500-1:2000,IHC-p:1:100-1:300,IF:1:200-1:1000,ELISA:1:10000。 尚未在其他应用中测试。
克隆性 多克隆
纯化工艺 使用表位特异性的免疫原,通过亲和层析,从兔抗血清中亲和纯化抗体。

商品属性

产品形式 液体溶液
浓度 1 mg/ml
储存缓冲液 含有50%甘油,0.5%BSA和0.02%叠氮化钠的PBS缓冲液。
保存建议 自发货之日起,-20°C可稳定保存1年。为最大限度的避免损失,请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。
运输条件 蓝冰运输
警告 本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。

附加信息

背景 Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known.
基因ID 120
别名 ADD3; ADDL; Gamma-adducin; Adducin-like protein 70
其它 该抗体可检测内源蛋白
蛋白质ID Q9UEY8

图片及说明

Fig.1. Western Blot analysis of various cells using Adducin γ Polyclonal Antibody.

Fig.1. Western Blot analysis of various cells using Adducin γ Polyclonal Antibody.

Fig.2. Western Blot analysis of 293 cells using Adducin γ Polyclonal Antibody.

Fig.2. Western Blot analysis of 293 cells using Adducin γ Polyclonal Antibody.

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