| 产品英文名称 | Collagen IV Mouse Monoclonal Antibody (4D1) |
| 免疫原 | 合成多肽： Collagen IV |
| 宿主 | 小鼠 |
| 反应性 | 人, 大鼠, 小鼠 |
| 应用 | IHC-P |
| 实验建议 | 最佳的工作稀释比例需要客户摸索优化。建议的起始尝试的稀释比为：IHC-p：1:50-200。 |
| 克隆性 | 单克隆 |
| 纯化工艺 | 使用表位特异性的免疫原，通过亲和层析，从小鼠腹水中亲和纯化抗体。 |
| 产品形式 | 液体溶液 |
| 浓度 | 1 mg/ml |
| 储存缓冲液 | PBS缓冲液（pH 7.4），含有0.02％叠氮化钠（防腐剂）和50％甘油。 |
| 保存建议 | 自发货之日起，-20°C可稳定保存1年。为最大限度的避免损失，请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。 |
| 运输条件 | 蓝冰运输 |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |
| 背景 | COL4A1 (collagen type IV alpha 1 chain) encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. COL4A1 shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in COL4A1 cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. |
| 基因ID | 1282 |
| 别名 | Collagen alpha-1(IV) chain |
| 其它 | 该抗体可检测内源蛋白 |
| 蛋白质ID | p02462 |
| 目标条带分子量（KD) | 161 |
Fig.1. Immunohistochemical analysis of paraffin-embedded Human Kidney Tissue using Collagen IV Mouse mAb diluted at 1:200.
Fig.2. Immunohistochemical analysis of paraffin-embedded Human Skin Tissue using Collagen IV Mouse mAb diluted at 1:200.
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