|产品英文名称||p38 Polyclonal Antibody|
|反应性||人, 大鼠, 小鼠|
|应用||ELISA, IF, IHC-P, WB|
|背景||Mitogen-activated protein kinase 14 encoded by MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs， or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of MAPK14 encoding distinct isoforms have been reported.|
|别名||MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein|
Fig.1. Western Blot analysis of various cells using p38 Polyclonal Antibody diluted at 1:1000.
Fig.2. Western Blot analysis of hela cells using p38 Polyclonal Antibody diluted at 1:1000.
Fig.3. Western Blot analysis of hela using p38 Polyclonal Antibody. Antibody was diluted at 1:1000.
Fig.4. Western Blot analysis of HepG2 using p38 Polyclonal Antibody diluted at 1:1000.
Fig.5. Western blot analysis of K562 lysis using p38 antibody. Antibody was diluted at 1:1000.
Fig.6. The picture was kindly provided by our customer.