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cAMP依赖蛋白激酶调控亚基IIβ多克隆抗体

PKA IIβ reg Polyclonal Antibody

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商品信息

产品英文名称 PKA IIβ reg Polyclonal Antibody
免疫原 合成多肽:人源蛋白PKA IIβ reg,非磷酸化多肽,中心氨基酸为S113.
宿主
反应性 人, 大鼠, 小鼠
应用 ELISA, IHC-P, WB
实验建议 最佳的工作稀释比例需要客户摸索优化。建议的起始尝试的稀释比为:WB:1:500-1:2000,IHC-p:1:100-1:300,ELISA:1:10000。 尚未在其他应用中测试。
克隆性 多克隆
纯化工艺 使用表位特异性的免疫原,通过亲和层析,从兔抗血清中亲和纯化抗体。

商品属性

产品形式 液体溶液
浓度 1 mg/ml
储存缓冲液 含有50%甘油,0.5%BSA和0.02%叠氮化钠的PBS缓冲液。
保存建议 自发货之日起,-20°C可稳定保存1年。为最大限度的避免损失,请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。
运输条件 蓝冰运输
警告 本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。

附加信息

背景 cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. Protein kinase cAMP-dependent type II regulatory subunit beta encoded by PRKAR2B is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
基因ID 5577
别名 PRKAR2B; cAMP-dependent protein kinase type II-beta regulatory subunit
其它 该抗体可检测内源蛋白
蛋白质ID P31323

图片及说明

Fig.1. Western Blot analysis of various cells using PKA IIβ reg Polyclonal Antibody.

Fig.1. Western Blot analysis of various cells using PKA IIβ reg Polyclonal Antibody.

Fig.2. Western Blot analysis of 3T3 cells using PKA IIβ reg Polyclonal Antibody.

Fig.2. Western Blot analysis of 3T3 cells using PKA IIβ reg Polyclonal Antibody.

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