|产品英文名称||PKC γ Polyclonal Antibody|
|免疫原||合成多肽：来源于中间区域的人源蛋白PKC γ. 氨基酸序列为： 150-230|
|反应性||人, 大鼠, 小鼠|
|背景||Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. Protein kinase C gamma encoded by PRKCG is one of the PKC family members. Protein kinase C gamma kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD， specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in protein kinase C gamma have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for PRKCG.|
|别名||PRKCG; PKCG; Protein kinase C gamma type; PKC-gamma|
Fig. Western Blot analysis of various cells using PKC γ Polyclonal Antibody.