|产品英文名称||Stat2 Polyclonal Antibody|
|反应性||人, 大鼠, 小鼠|
|应用||ELISA, IHC-P, WB|
|实验建议||最佳的工作稀释比例需要客户摸索优化。建议的起始尝试的稀释比为：WB：1:500-1:2000，IHC-p：1:100-300 ELISA：1:10000。 尚未在其他应用中测试。|
|背景||Signal transducer and activator of transcription 2 encoded by STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN， this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G， in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.|
|别名||STAT2; Signal transducer and activator of transcription 2; p113|
Fig.1. Western Blot analysis of extracts from K562 cells, using Stat2 Polyclonal Antibody. Secondary antibody (catalog#: A21020) was diluted at 1:20000.
Fig.2. Immunohistochemical analysis of paraffin-embedded rat-lung, antibody was diluted at 1:100.
Fig.3. Immunohistochemical analysis of paraffin-embedded rat-lung, antibody was diluted at 1:100.
Fig.4. Immunohistochemical analysis of paraffin-embedded Mouse-lung, antibody was diluted at 1:100.
Fig.5. Immunohistochemical analysis of paraffin-embedded Mouse-lung, antibody was diluted at 1:100.