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p16 (phospho Ser326)多克隆抗体

p16 (phospho Ser326) Polyclonal Antibody

浏览次数(16) 文献引用(0) 货号(ABP53457)
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商品信息

产品英文名称 p16 (phospho Ser326) Polyclonal Antibody
免疫原 合成多肽:人源蛋白p16,磷酸化多肽,中心氨基酸为S326.
宿主
反应性
应用 ELISA, IHC-P, WB
实验建议 最佳的工作稀释比例需要客户摸索优化。建议的起始尝试的稀释比为:WB:1:500-1:2000,IHC-p:1:100-1:300,ELISA:1:5000。 尚未在其他应用中测试。
克隆性 多克隆
纯化工艺 使用表位特异性的免疫原,通过亲和层析,从兔抗血清中亲和纯化抗体。

商品属性

产品形式 液体溶液
浓度 1 mg/ml
储存缓冲液 含有50%甘油,0.5%BSA和0.02%叠氮化钠的PBS缓冲液。
保存建议 自发货之日起,-20°C可稳定保存1年。为最大限度的避免损失,请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。
运输条件 蓝冰运输
警告 本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。

附加信息

背景 CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
基因ID 1029
别名 CDKN2A; CDKN2; MTS1; Cyclin-dependent kinase inhibitor 2A; isoforms 1/2/3; Cyclin-dependent kinase 4 inhibitor A; CDK4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4A
其它 该抗体可检测内源蛋白
蛋白质ID P42771

图片及说明

Fig.1. Western Blot analysis of JK cells using Phospho-p16 (S326) Polyclonal Antibody diluted at 1:500.

Fig.1. Western Blot analysis of JK cells using Phospho-p16 (S326) Polyclonal Antibody diluted at 1:500.

Fig.2. Western Blot analysis of 22RV1 HELA cells using Phospho-p16 (S326) Polyclonal Antibody diluted at 1:500.

Fig.2. Western Blot analysis of 22RV1 HELA cells using Phospho-p16 (S326) Polyclonal Antibody diluted at 1:500.

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