||MAST1 (Microtubule Associated Serine/Threonine Kinase 1) is a Protein Coding gene. MAST1 is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by MAST1 has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system.