重组小鼠骨保护素蛋白(OPG),His-标签
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重组小鼠骨保护素蛋白(OPG),His-标签

Recombinant Mouse OPG Protein,His tag

浏览次数(16098) 货号(PRP1953)
Recombinant Mouse OPG Protein,His tag
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商品信息

产品英文名称 Recombinant Mouse OPG Protein,His tag
产品中文名称 重组小鼠骨保护素蛋白(OPG),His-标签
别名 Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; Tnfrsf11b; Ocif; Opg

商品属性

种属小鼠
纯度>95% ,使用SDS-PAGE检测
特点&优势采用 LAL 法检测,每 1 μg 蛋白质中的 EU 含量小于1.0。
产品形式Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
基因ID18383
蛋白序列链接https://www.uniprot.org/uniprotkb/O08712/entry
使用中注意事项Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
保存建议Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
警告本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。

附加信息

背景Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG inhibits TRAIL-induced apoptosis. Expression of RANK L on the cell surface, and thus its ability to stimulate osteoclastogenesis, is regulated by OPG by intracellular and extracellular mechanisms. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. It may also play a role in preventing arterial calcification.

图片及说明

Fig.PRP1953 - 重组人碱性成纤维细胞生长因子(FGF-b)

Fig.PRP1953 - 重组人碱性成纤维细胞生长因子(FGF-b)

使用说明

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