| 产品英文名称 | Human GDF-15 Protein, His Tag |
| 产品中文名称 | 重组人生长分化因子15，His标签 |
| 别名 | GDF15; GDF-15; growth differentiation factor 15; growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; NAG-1; PDF; PDFGDF-15; PLAB; PLABNRG-1 |
| 宿主 | Yeast |
| 序列 | A DNA sequence encoding the mature form of human GDF15(Ala197-Ile308) was expressed with a polyhistidine tag at the N-terminus. |
| 活性 | Immobilized Recombinant Human GDF-15 Protein (His Tag) at 2 μg/mL (100 μL/well) can bind Recombinant Human GFRAL Protein (Fc Tag), the EC50 is 7.0-21.0 ng/mL. |
| 蛋白长度 | 13.7 kDa |
| 产品形式 | Lyophilized from sterile 50mM HAc, pH 2.9. |
| 保存建议 | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| 运输条件 | 冰袋运输（蓝冰） |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |
| 背景 | Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression. |
Fig.Human GDF-15 Protein, His Tag
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